Pharmacogenomics is a quickly evolving field of research that increasingly impacts individuals and society. As some innovations in biotechnology have experienced strong public opposition during the 1990s, interaction between producers and users of these innovations may help in increasing their success in social and economic terms. However, conditions for effective interaction have so far remained under-explored. This paper explores user-producer interactions in pharmacogenomics from an innovation and science communication perspective in the Netherlands. To find possible ways of engaging stakeholders in (...) an early stage of technology development, ie, when science policy is in the making, we present communication activities derived from the field of policy analysis. To articulate motives for two-way public participation in genomics innovation processes, we describe two levels at which pharmacogenomics developments will have an input:1) at the meso-level of medical practice with already established medical technologies, values and routines, suppliers and health professionals (general practitioners, pharmacists), and 2) at the macro-level of society at large, with established institutions, infrastructures, and broadly shared values and beliefs among citizens in general. Thereby we offer a starting point for optimising decision-making processes in the field of pharmacogenomics innovations, including important aims to be reached, stakeholders to be involved, and some criteria for designing interactive communication activities. (shrink)

Amongst the people who pester Peisthetaerus with unwanted help and advice in the latter part of the Birds is Meton, famous astronomer and mathematician, who produces and demonstrates with instruments a method of laying out the plan of the new town. Peisthetaerus makes no attempt to follow him and quickly bundles him out again without much ceremony. Commentators and readers with few exceptions treat him in a similar way. ʹΕπίτηδες δανόητα, δόλου νοηταίνε, παίζε—such are the comments of the scholiast, and (...) editors are mostly content with that. Van Leeuwen says, ‘Metonis haec verba intellegere velle, id est operam dare ut suo ioco frustretur cbtnicus.’ The passage is of course highly comical; to make it didactic and attribute to Aristophanes a serious excursion into geometry and town-planning would be perverse and pedantic; but in Aristophanes more than in most comic writers there is commonly a grain or two of truth among the chaff. These grains, though of little or no importance for the appreciation of the play as comedy, may still have some possible value in other ways, and should be carefully sifted. (shrink)

It is argued that a radical relocation of subjectivity began several thousand years ago. A subjectivity experienced in the centric region of the heart, and in the body as a whole, began to be avoided in favor of the eccentric head as a new location of subjectivity. In ancient literature, for example in Homer's epics, the heart and various other bodily organs were described as centers of subjectivity and organs of perception for spiritual experience and communion with others and the (...) world. Mind and body were integrated. Bur also in the early historical record, as in the Old Testament, the heart and body were increasingly described as rebellious and rejected as impure. Head and heart, mind and body, became estranged. The body was judged an unsuitable, impure vessel for spiritual experience. This change in the location of subjectivity presaged the later development of Platonic, Gnostic, Christian, and Cartesian distinctions favoring mind over and against the body. It may also have contributed to some of the characteristic psychological and pathological processes (e.g., psychosomatic illnesses, repression, narcissism) currently attributed to the psychology of the modern Western, and specifically, North American self. (shrink)

We formulate a restricted version of the Tukey-Teichmüller Theorem that we denote by (rTT). We then prove that (rTT) and (BPI) are equivalent in ZF and that (rTT) applies rather naturally to several equivalent forms of (BPI): Alexander Subbase Theorem, Stone Representation Theorem, Model Existence and Compactness Theorems for propositional and first-order logic. We also give two variations of (rTT) that we denote by (rTT)+ and (rTT)++; each is equivalent to (rTT) in ZF. The variation (rTT)++ applies rather naturally to (...) various Selection Lemmas due to Cowen, Engeler, and Rado. (shrink)

This distinction has sometimes been read as purely epistemic, resting not on things, but on our knowledge of them: there is one world, not two, though it may be apprehended in two ways. But this view is patently at odds with the text. Knowledge and opinion are δυνάμεις, "faculties," to be distinguished and defined by their objects, no less than by the state of mind they produce, and Plato clearly states that the fallibility and unclearness of opinion is rooted in (...) the relative unreality of opinables. (shrink)

This paper is an experiment in Leibnizian analysis. The reader will recall that Leibniz considered all true sentences to be analytically so. The difference, on his account, between necessary and contingent truths is that sentences reporting the former are finitely analytic; those reporting the latter require infinite analysis of which God alone is capable. On such a view at least two competing conceptions of entailment emerge. According to one, a sentence entails another when the set of atomic requirements for the (...) first is included in the corresponding set for the other; according to the other conception, every atomic requirement of the entailed sentence is underwritten by an atomic constituent of the entailing one. The former conception is classical on the twentieth century understanding of the term; the latter is the one we explore here. Now if we restrict ourselves to the formal language of the propositional calculus, every sentence has a finite analysis into its conjunctive normal form. Semantically, then, every sentence of that language can be represented as a simple hypergraph, H, on the powerset of a universe of states. Entailment of the sort we wish to study can be represented as a known relation, subsumption between hypergraphs. Since the lattice of hypergraphs thus ordered is a DeMorgan lattice, the logic of entailment thus understood is the familiar system, FDE of first-degree entailment. We observe that, extensionalized, the relation of subsumption is itself a DeMorgan Lattice ordered by higher-order subsumption. Thus the semantic idiom that hypergraph-theory affords reveals a hierarchy of lattices capable of representing entailments of every finite degree. (shrink)

One major milestone in the development of the sea urchin embryo is the assembly of a single cilium on each blastomere just before hatching. These cilia are constructed both from pre‐existing protein building blocks, such as tubulin and dynein, and from a number of 9+2 architectural elements that are synthesized de novo at ciliogenesis. The finite or quantal synthesis of certain key architectural proteins is coincident with ciliary elongation and proportional to ciliary length. Upon deciliation, the synthesis of architectural proteins (...) occurs anew, a new cilium grows, and the stores of various building blocks are replenished. This routine of coordinated ciliary gene expression may be replayed experimentally many times without delaying normal development. The ability to regenerate cilia has allowed elucidation of these various protein synthetic relationships and has led to the discovery of the pathways by which membrane‐associated tubulin and axoneme‐associated architectural proteins are conveyed into the highly compartmentalized growing cilium. The sea urchin embryo thus provides a very convenient model system for studies of ciliary assembly and maintenance, coordinate gene expression and membrane dynamics. (shrink)

J. Krishnamurti (1895-1986) was thought by many to be a modern-day equivalent of the Buddha. In fact, he was once even considered to be the second coming of Christ. While many think it wonderful to live and work in close proximity with such a person, it's difficult to understand the depth of what this means and how challenging this might be. In Knocking at the Open Door, author R.E. Mark Lee provides an ordinary person view of what being close-up and (...) working together with such a man means, how it challenges one at every turn, and how it causes one to question ceaselessly, even more deeply than one ordinarily would. Lee offers an insightful, candid, and heartfelt narrative that reveals various unknown facets of the eminent world teacher J. Krishnamurti and highlights his distinctive vision for education worldwide. This comprehensive volume brings alive the practical and everyday interactions Lee had with Krishnamurti during a twenty-year period in India and the United Sates. Knocking at the Open Door shares a clear and honest account that demonstrates the challenges of working with Krishnamurti in running a school that is true to the teaching and yet able to function in the reality of modern parental, student, and educational establishment expectations. (shrink)

Si bien la importancia de Avicena como fuente del pensamiento de Tomás de Aquino es generalmente reconocida, los detalles de esa dependencia apenas comienzan a trabajarse. Este artículo se ocupa de las enseñanzas de Avicena en lo que respecta a los “sujetos” de las ciencias teoréticas —física, matemáticas y metafísica— tal y como se presentan en la Introducción al Libro de la Curación. Posteriormente, se muestra su influencia en el comentario de Tomás de Aquino al De trinitate, de Boecio, q. (...) 5, art. 1. A través de una comparación entre Avicena y Tomás se muestra la profunda influencia que tuvo Avicena en la comprensión tomista del rango de las tres clases de ciencias teoréticas. (shrink)

While the importance of Avicenna as a source of Aquinas’s thought is generally recognized, the details of that dependence are just now being worked out. This article presents Avicenna’s teaching on the “subjects” of the theoretical sciences—physics, mathematics, and metaphysics—as presented in his Introduction to the Book of Healing. Its influence on Aquinas’s commentary on Boethius’s De trinitate, q. 5, art. 1, is then presented. Comparing Avicenna with Thomas in this way shows the profound influence of Avicenna on Thomas’s understanding (...) of the range of the three kinds of theoretical sciences. (shrink)

The development of virtue ethics in the contemporary philosophical world, as a reaction to various forms of consequentialism, deontology, and moral skepticism, has now brought forth translators determined to offer the wisdom of pre-moderns to contemporary readers. Here is a “small work” of Denis , the “last of the scholastics” and a contemporary of humanists like Ficino and Erasmus, who opened the modern age that is now rapidly closing. Educated in “the way of Thomas Aquinas” at the University of Cologne, (...) the Carthusian cloister allowed him leisure to become a prolific author, often cited by Catholics during the Protestant Reformation.He should be rescued from obscurity, for here he weaves together the vices and virtues in a way that eluded even Aquinas. In the spirit of the age, his audience was the ordinary layman. Denis brought Thomistic materials together with Scripture and the Fathers, using the Neoplatonic circle made famous by his namesake, Dionysius the Areopagite. Book One charts how sin pushes us ever deeper through the seven deadly sins. Then Book Two follows the workings of grace and nature in producing progress in virtue. Especially insightful is the way Denis uses Plotinus to. (shrink)

Here, I should like to tell a story, beginning with how the works of Aristotelian philosophy came to exist in Latin translations, then moving to the project of transforming Christian theology into an Aristotelian “science.” After that, I would like to look a bit more closely at the case of Br. Thomas of Aquino and his dependence upon the Muslim philosopher Ibn Sīnā. Finally, I shall end by drawing some wider conclusions based upon this important example.

The first chapter discusses the association of the English word ‘or’ in reasoning. “Or” is descended from the Anglo-Saxon word meaning second, a form which survives in such expressions as “every other day.” If logical theory had not introduced the vocabulary of disjunction, we could not formulate the question. The truth-functional character of ‘or’ and ‘and’, if they have such a character in their natural language habitat, is a character that is derived as a consequence of their playing a certain (...) role in discourse, one best described as punctuation, or in a specialized sense of the word adverbial. In many cases, the transformation of a sentence embedding an or-list to an equivalent or joined pair of sentences cannot plausibly be called disjunctive distribution. ‘Or’-words derive from additive rather than from subtractive ancestors. (shrink)

This chapter describes logic and the significance of punctuation to ‘or’ in a sentence. Axioms are primitive theorems. This is what is meant by ‘logic’, and in particular, a propositional logic is one that can be specified. Deontic logicians are by no means unanimous about their point of formal departure: whether it is the language of ‘ought’ and ‘may’ or the language of ‘obligation’ and ‘permissibility’. The punctuationist account takes ‘or’ as providing punctuation for lists and asks why we should (...) punctuate a list with ‘or’ in certain contexts when we want it to receive a conjunctive reading. ‘Or’ can be replaced by ‘else’ or ‘otherwise’, ‘or’ is a relative adverb as well. ‘Or’ can be regarded as a modifier of a whole sentence. (shrink)

This chapter examimes relevance to misunderstandings about the meaning of aut and possible meanings of ‘or’. In spite of what has been said about the notion of form, there is no harm in applying the word ‘formal’ to the Stoics' work. By some standards, it is not informal, and by those standards, we may therefore call it formal where it is the contrast intended. Since the substitution account of validity would not rule out such disjunctions and a descriptive account would, (...) the descriptive account seems on that score to be the more likely candidate for the Stoic conception of validity. Boole also took exclusivity, even the same arity-free idea of exclusivity, to be centrally important to his representation, but the exclusivity was constructed out of a non-exclusive disjunctive use of ‘or’. (shrink)

Roman Catholic bioethics seems to be caught in a paradox. One the one hand it is committed to the natural law tradition and the power of reason to understand the structures of creation and the moral law. On the other hand there is a greater and greater appeal to Scripture and revelation. The tradition maintains that reason is capable of understanding the rational structures of reality and that ethics is properly built on metaphysics. In this way ethics, bioethics, is non-sectarian. (...) However, the tradition also recognizes the effects of Original Sin on the will and intellect and the broad cultural changes that have affected our understanding of metaphysics. The appeal to Revelation is a corrective to many contemporary trends in ethics and bioethics. This article will examine the interplay of reason and revelation in the Church's teaching on sexuality, (particularly contraception and in vitro fertilization), suffering, and death. Catholic bioethics is in the end prophetic and ecumenical and not gnostic and non-ecumenical. (shrink)

The issues relating to the licensing of a biopharmaceutical are described. In particular attention is focused on the mind of the regulator who has the responsibility of recommending licensure. There are two key factors which operate on the mind when confronted with such a task: psychology and ethics. The different factors which influence the psychological acceptability of a product for licensure are many and varied; they include perceived need, novelty, education, context and others. Also involved is the regulator’s view of (...) the ethicality of such products and the organisms which make them, with particular reference to those which are genetically engineered. These ethical views are in turn derived by reference to basic systems of ethics which provide guidelines for behavior. It is important for the manufacturers of biopharmaceuticals to be aware of both the psychological and ethical aspects of the regulator’s mind when addressing such individuals with a view to obtaining a license to manufacture a particular biopharmaceutical. (shrink)

We hear much of voodoo science or junk science or even scientific science, in this paper I seek to evaluate and understand how we might approach a description of the qualities of science. In this I base my reasoning on the equivalence of the words science and knowledge. I then note that the application of the scientific method determines how confident we may be in what we hold as knowledge or science (basically a tested guess or hypothesis). The different levels (...) of confidence are reflected in a variety of terms, including: good or bad, junk or valuable, voodoo or reliable. (shrink)

The thesis of this article is that there has never been any ground for the controversy between the doctrine of free will and determinism, that it is based upon a misapprehension, that the two assertions are entirely consistent, that one of them strictly implies the other, that they have been opposed only because of our natural want of the analytical imagination. In so saying I do not tamper with the meaning of either phrase. That would be unpardonable. I mean free (...) will in the natural and usual sense, in the fullest, the most absolute sense in which for the purposes of the personal and moral life the term is ever employed. I mean it as implying responsibility, merit and demerit, guilt and desert. I mean it as implying, after an act has been performed, that one " could have done otherwise " than one did. I mean it as conveying these things also, not in any subtly modified sense but in exactly the sense in which we conceive them in life and in law and in ethics. These two doctrines have been opposed because we have not realised that free will can be analysed without being destroyed, and that determinism is merely a feature of the analysis of it. And if we are tempted to take refuge in the thought of an "ultimate ", an "innermost" liberty that eludes the analysis, then we have implied a deterministic basis and constitution for this liberty as well. For such a basis and constitution lie in the idea of liberty. -/- The thesis is not, like that of Green or Bradley, that the contending opinions are reconciled if we adopt a certain metaphysic of the ego, as that it is timeless, and identifies itself with a desire by a " timeless act". This is to say that the two are irreconcilable, as they are popularly supposed to be, except by a theory that delivers us from the conflict by taking us out of time. Our view on the contrary is that from the natural and temporal point of view itself there never was any need of a reconciliation but only of a comprehension of the meaning of terms. (The metaphysical nature of the self and its identity through time is a problem for all who confront memory, anticipation, etc.; it has no peculiar difficulties arising from the present problem.) -/- I am not maintaining that determinism is true; only that it is true insofar as we have free will. That we are free in willing is, broadly speaking, a fact of experience. That broad fact is more assured than any philosophical analysis. It is therefore surer than the deterministic analysis of it, entirely adequate as that in the end appears to be. But it is not here affirmed that there are no small exceptions, no slight undetermined swervings, no ingredient of absolute chance. All that is here said is that such absence of determination, if and so far as it exists, is no gain to freedom, but sheer loss of it; no advantage to the moral life, but blank subtraction from it. -- When I speak below of "the indeterminist" I mean the libertarian indeterminist, that is, him who believes in free will and holds that it involves indetermination. (shrink)

This study represents an improvement in the ethics scales inventory published in a 1988 Journal of Business Ethics article. The article presents the distillation and validation process whereby the original 33 item inventory was reduced to eight items. These eight items comprise the following ethical dimensions: a moral equity dimension, a relativism dimension, and a contractualism dimension. The multidimensional ethics scale demonstrates significant predictive ability.

Open peer commentary on the article “The Circular Conditions of Second-order Science Sporadically Illustrated with Agent-based Experiments at the Roots of Observation” by Manfred Füllsack. Upshot: I follow the general tenor of Füllsack’s target article but I have some basic reservations as to the utilization of the thermodynamics involved.

Should we let personal responsibility for health-related behavior influence the allocation of healthcare resources? In this paper, we clarify what it means to be responsible for an action. We rely on a crucial conceptual distinction between being responsible and holding someone responsible, and show that even though we might be considered responsible and blameworthy for our health-related actions, there could still be well-justified reasons for not considering it reasonable to hold us responsible by giving us lower priority. We transform these (...) philosophical considerations into analytical use first by assessing the general features of health-related actions and the corresponding healthcare needs. Then, we identify clusters of structural features that even adversely affected people cannot reasonably deny constitute actions for which they should be held responsible. We summarize the results in an analytical framework that can be used by decision-makers when considering personal responsibility for health as a criterion for setting priorities. (shrink)

Translational ethics (TE) has been developed into a specific approach, which revolves around the argument that strategies for bridging the theory‐practice gap in bioethics must themselves be justified on ethical terms. This version of TE incorporates normative, empirical and foundational ethics research and continues to develop through application and in the face of new ethical challenges. Here, I explore the idea that the academic field of bioethics has not yet sufficiently analysed its own philosophical foundation for how it can, and (...) should, be practically relevant; neither has it comprehensively discussed the limitations on what impacts bioethicists should pursue. As a result, there has not been adequate training on how to suitably and appropriately impact real‐world practices. Moreover, bioethical perspectives are often competing with other strong interests, for example, economic and political, which may weaken their impact on policy‐making. The TE approach I propose can not only facilitate practical impacts of academic bioethics by being better informed by real‐world ethical issues but it also supports targeted and ethical justifications of the actual impact of academic work in real‐world contexts. In this paper, I clarify the premises for this TE approach, identify further challenges and sketch out potential solutions for the implementation of this methodological framework. (shrink)